Are there other mechanisms by which pills cause weight gain?
In one study of pills, a formulation containing desogestrel as the progestin and slightly less estrogen had significantly less weight gain when compared to a pill containing norethindrone (Ortho Novum 7/7/7®). This may imply that the specific progestin has a role in weight gain, possibly through a lesser degree of insulin resistance. Or it could be the combination of lower estrogen and the specific progestin but in any case, there was less weight gain. Currently marketed pills with desogestrel as the progestin are Desogen® and Ortho-Cept®.
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